Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidines and Purine Nucleosides
نویسندگان
چکیده
منابع مشابه
Purines, Purine Nucleosides, and Analogues
Of 142 purines, purine nucleosides, and analogues tested for inhibition of growth of Escherichia coli B Hill, 45 were active. Of these, 27 were evaluated for inhibition of other E. coli lines, including those resistant to 6-thioguanine, 2-fluoroadenosine, 2,6-diaminopurine, or 6-mercaptopurine. Most toxic to the parent lines were 2-fluoroadenosine, 2-fluoroadenine, 2-fluoro-5'-deoxyadenosine, a...
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To test the hypothesis that carcinostatic purine and pyrimidine analogues exert their effects at the nucleotide level, we have undertaken the preparation and study of nucleotides, including coenzymes, which contain analogues in place of the natural bases. An earlier communication from this laboratory (1) described the enzymatic synthesis and isolation of 5’-nucleotides of a number of purine ana...
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The absorption and metabolism of dietary nucleic acids have received less attention than those of other organic nutrients, largely because of methodological difficulties. We supplemented the rations of poultry and mice with the edible alga Spirulina platensis, which had been uniformly labeled with '3C by hydroponic culture in 13CO2. The rations were ingested by a hen for 4 wk and by four mice f...
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Even a short blockade of oxygen flow in brain may lead to the inhibition of oxidative phosphorylation and depletion of cellular ATP, which results in profound deficiencies in cellular function. Following ischemia, dying, injured, and hypoxic cells release soluble purine-nucleotide and -nucleoside pools. Growing evidence suggests that purine nucleosides might act as trophic factors in the CNS an...
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The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are shown to be catalyzed by the same enzymes which similarly convert the natural subst...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 1994
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo00103a013